HCG Side Effects – Cholesterol Update
By Dr. Dennis Clark | Posted under HCG Side Effects | 8 CommentsRecent research on hCG side effects shows a reduction in cholesterol levels during the hCG diet protocol. Here is what you can expect.
HCG Side Effects – A Benefit
More than 50 years ago Dr. Simeons described and predicted the effects of his protocol on reducing cholesterol levels. A recent study, published in 2011, examined changes in blood lipids and confirmed Dr. Simeons’ original claims.
The study in question evaluated several outcomes of the hCG diet protocol. The main results of interest (i.e., weight loss and fat reduction) were summarized in an earlier post here: HCG Diet Plan – Real Science.
Statistically significant changes in blood lipid profiles are highlighted by blue arrows in Table 2 from that study below. Data represent mean values plus or minus one standard deviation. This may seem like statistical mumbo jumbo, which it is. However, calculations of statistical significance use of the level variability around the means (i.e., averages) to infer whether the differences “Pre” and “Post” treatment are meaningful.
Those comparisons that can be considered meaningful statistically (blue arrows) are: reduction in total cholesterol, reduction in LDL cholesterol, reduction in the ratio of total cholesterol to HDL cholesterol, and reduction in the ratio of LDL cholesterol to HDL cholesterol. See below.

Comments
It is wonderful to see Dr. Simeons’ comments about total cholesterol confirmed. His observation that the hCG diet has the effect of loosening cholesterol-bound plaque seems to be corroborated. This study did not, however, measure the progress of that change over time. It would have been interesting to see to what extent cholesterol levels might spike during the protocol, also as predicted by Dr. Simeons, before dropping down at the end of the study.
Modern medicine knows more about types of bound cholesterol now: HDL, LDL, and VLDL. The general guidelines point to more HDL, less LDL and less VLDL as indicators of better cardiovascular health.
The results of this study are nice to know regarding changes in cholesterol during the hCG diet protocol. They can be considered beneficial hCG side effects by many. Although this is good news, it is superficial. In fact, it is well known by many clear thinkers in modern medicine that the issue of cholesterol vs. cardiovascular health is an artificial one that does not serve human health. It only serves a giant pharmaceutical industry that markets cholesterol-lowering drugs. This is a book-length topic, which books and articles have already been written about for more than 40 years. A single blog post could not possible do justice to it. I encourage you to do your own research on it, and while you are doing so, simply do not worry about your cholesterol. It would be pointless.
What About Triglycerides?
Levels of circulating triglycerides may be a more important indicator of health in several ways. Keeping triglycerides under control is a good idea. The data in this study, however, show that among the subjects who underwent blood work, triglyceride levels were highly variable (i.e., large standard deviations around the means). This just means that, in looking at the results, the trend of lowered triglyceride levels from “Pre” to “Post” study measurements was not statistically significant. This is indicated by the green arrow in the table.
The same goes for an apparent drop in VLDL. Statistically, it is not a meaningful reduction.
Updating hCG side effects,
Dr. D





by Virginia Boyce
I would love to get your comments on this. I have done several successful rounds of HCG, and had blood drawn within a few weeks after completeing a round, twice. Both times my cholesterol and LDL were sky high, alarming both myself and my PCP. Have you seen this kind of elevation a few weeks after stopping, and if so, have you also seen the numbers tend to normailize again, and in what time frame? I’m wondering now how long to wait to get tested again. I’m eating a wonderfully healthy diet currently to maintain my fat loss. PS I really have benefitted from your material on all of this. Thanks
by Dr. Dennis Clark
Hi, Virginia:
No, I have not heard of that cholesterol variability before. The logic of saying that high levels of circulating indicate plaque buildup is flawed, though. The problem is cholesterol that sticks to damaged arterial walls, which is a result of inflammation. There is only about a 50% correlation between high cholesterol and arterial blockage. However, the correlation is 100% between inflammation and arterial blockage. A good diet helps keep inflammation down, so it sounds as though you are on track. And thanks for your kind comments!
All the best,
Dennis
by Ginger
I have reviewed your information looking specifically for HCG protocal and its compatibility with IBS flare ups and the use of probiotics. I successfully lost 25 lbs with HSG drops, and want to use again, but need to monitor my diet for triggers and reduce symptons beore I try another go-round. Will appreciate your thoughts, comments and/or suggestions.
by Dr. Dennis Clark
Hi, Ginger:
Taking probiotics is the best thing you can do naturally. Make sure you have a product with several kinds of bacteria (5-15) and take doses of 5 billion cells minimum. If you have a flare-up, you can take a probiotic medical food called VSL3 (vsl3.com), which provides a 450 billion cell dose. If you are up for an experiment, do a gluten-free diet for a month. Results for stopping IBS can be miraculous.
All the best,
Dennis
by jeff
Will HCG ever become FDA approved as a diet aid???
by Dr. Dennis Clark
Hi, Jeff: I suspect not. However, in my opinion, it is a good thing when the FDA is not involved. It is a rogue government agency that serves the interests of the pharmaceutical industry, without much benefit to human health.
All the best,
Dennis
by Donna Tisdale
I completed my HCG drops on Thanksgiving 2011. I had a cholesterol test in January 18, 2012. It registered at 267. That was the highest it had ever been. I was shocked. After researching on the internet today, I find that this is normal. I don’t know how long it will take to go down, but I am anxiously awaiting. I am scheduled to take another cholesterol test tomorrow morning and I am 13 days into Round 2 of my HCG diet. I would also like to know how long do I have to wait to get a more normal reading after the protocol. FYI, I do love this diet. This is the most successful diet that I have been on. Thanks for the info.
by Dr. Dennis Clark
Hi, Donna: Just be sure to eat an anti-inflammatory diet, with good supplements (fish oils, etc.). Your cholesterol level will then be irrelevant.
All the best,
Dennis